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Publications Portfolio
Medical Writing
Navigating the Lifecycle of a Malaria PKPD Model
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From Complex Raw Data to Published Authority in CPT:PSP
The Client: Medicines for Malaria Venture (MMV)
The Publication: CPT: Pharmacometrics & Systems Pharmacology
The Role: Editorial Lead & Medical Writing Consultant
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The Challenge: A “Hidden” Stage of Infection
The development of new malaria chemoprophylactics is hindered by a significant knowledge gap: liver-stage activity cannot be directly observed in humans. The research team at MMV had developed a sophisticated semimechanistic PKPD model using DSM265 (a DHODH inhibitor) to infer liver-stage growth and initial infection levels by integrating blood-stage and sporozoite-infected human challenge data.
While the modeling was robust, the manuscript faced the hurdle of all high-level pharmacometrics: communicating a multi-stage, multi-compartment model in a way that was both scientifically rigorous for specialists and clear enough for broader clinical stakeholders.
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The Solution: Editorial Translation & Strategy
I was brought in to spearhead the editorial development of the manuscript. My work didn’t involve the Monolix simulations, but rather the narrative engineering required to present them.
Structural Refinement: I tidied the initial rough draft, ensuring the transition from the methodology of Induced Blood-Stage Malaria (IBSM) studies to the complexities of the liver-stage model was logically seamless.
Precision in Communication: I refined the presentation of the model’s core equations, such as the turnover model for KillL and KillB, ensuring that parameters like Emax, EC50, and the Hill coefficient (h) were described with absolute clarity.
Peer Review Stewardship: After submission, I managed the revisions following peer review. This involved interpreting reviewer feedback and refining the text to address technical concerns without diluting the paper’s primary message: that liver activity can be inferred to predict clinical outcomes.
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The Result: A Milestone for Malaria Prophylaxis
The paper was successfully published in CPT: Pharmacometrics & Systems Pharmacology in late 2022. It demonstrated that by assuming similar characteristics between liver and blood-stage activities, researchers could accurately predict the level of chemoprotection afforded by new compounds.
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Validating Gene Therapy Scaling in Ophthalmology
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Bridging the Gap from Monkey to Man in Molecular Pharmaceutics
The Client: LYO-X AG
The Publication: Molecular Pharmaceutics (ACS Publications)
The Role: Senior Editorial Consultant & Submission Strategist
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The Challenge: A “Premature” Verdict
Gene therapy is one of the most complex frontiers in pharmacometrics because it replaces standard mass-balance drug kinetics with biological processes like cellular transduction. Florian Hugi and the team at LYO-X developed a pioneering semimechanistic model to predict human dose-exposure for ADVM-022 (a wAMD gene therapy) by scaling data from non-human primates.
During the initial peer-review phase at Molecular Pharmaceutics, the manuscript faced a critical hurdle. Reviewers were skeptical, with one labeling the research as “premature” due to the inherent novelty of gene therapy scaling. With the LYO-X team facing significant time constraints, the paper required a rapid, high-level strategic intervention to survive the review cycle.
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The Solution: Strategic Resubmission & Narrative Defense
I was brought in not just to edit, but to manage the entire submission lifecycle and overhaul the manuscript’s defensive posture.
Addressing Skepticism: I took the lead on the “Response to Reviewers,” carefully reframing the “premature” nature of the data as a vital “first-of-its-kind” framework that the field required for first-in-human dose predictions.
Subscript & Variable Precision: I ensured the rigorous formatting of complex ocular PK variables, such as aqueous clearance (CLaq), vitreous-aqueous elimination (kel,va), and maximal retinal expression (kmax,ret).
- Scaling Narrative: I refined the explanation of how the model decoupled target protein kinetics from the less understood gene therapy scaling, making the animal-to-human translation biologically plausible to the editors.
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By taking over the heavy lifting during the revision phase, I helped move the paper from a precarious position to a successful publication in July 2025. The final model successfully predicted human intraocular aflibercept levels observed in the OPTIC Phase 1 trial, proving the utility of the LYO-X framework.
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Advancing Malaria Prophylaxis Modeling
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(In Development)
Simulating Real-World Transmission Dynamics in Preventive Chemotherapy
The Client: Confidential (Global Health Non-Profit & Pharmaceutical Leaders)
The Status: In Press / Under Development (2025–2026)
The Role: Senior Medical Writing Consultant & Editorial Strategist
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The Challenge: Beyond the “Single-Bite” Model
While initial pharmacokinetic-pharmacodynamic (PKPD) models provide a foundation for drug activity, they often focus on a single, controlled infection. To better inform late-stage clinical trials, a more robust framework was required, one that could simulate the intensity of natural malaria transmission in endemic regions, accounting for multiple mosquito bites and varying levels of patient treatment adherence.
This project involved reconciling data across a complex ecosystem of stakeholders, including leading global health organizations and multinational pharmaceutical firms, to create a model that could predict Protective Efficacy (PE) in diverse field conditions.
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The Solution: Narrative Cohesion for Multi-Stakeholder Research
As the lead editorial consultant, my role focused on the translational bridge between high-level stochastic modeling and regulatory-ready scientific narrative.
Complexity Management: I am responsible for maintaining the narrative thread of the research as it evolves from a liver-stage PK focus to a sophisticated framework incorporating Force of Infection (FOI) and Incidence Rate Ratio (IRR).
Stakeholder Stewardship: With lead researchers now at disparate organisations, I act as the central editorial point to ensure the manuscript remains cohesive and maintains the rigorous standards of journals like CPT: Pharmacometrics & Systems Pharmacology.
- Strategic Sensitivity Analysis: I am currently refining how the manuscript presents sensitivity analyses, particularly regarding assumptions of drug activity during different stages of the parasite lifecycle and the impact of non-adherence on protective outcomes.
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The output of this project is a modeling framework that allows organisations to swiftly position candidate compounds based on predefined protective efficacy targets. By bringing the modeling closer to a “field perspective,” this work directly informs the design of Phase IIb and Phase III clinical trials.
Predicting Human PK for Half-Life Extended mAbs
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(In Development)
A Comprehensive Cross-Species Scaling Framework
The Client: Confidential (Strategic Partnership)
The Status: Manuscript Finalised (Conditionally Accepted/Minor Corrections)
The Role: Lead Narrative Architect & Submissions Manager
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The Challenge: The Engineering vs. Scaling Gap
Monoclonal antibodies (mAbs) are often engineered with specific mutations (such as LS and YTE) to enhance their affinity for the FcRn receptor, effectively prolonging their circulatory half-life from ~20 days to upwards of 60+ days. While the benefits are clear, predicting exactly how these engineered antibodies will scale from preclinical species (mice and monkeys) to humans remains a significant challenge for drug developers.
A framework was needed that could unify disparate datasets, incorporating wt (wild-type), LS, and YTE variants across multiple species, into a single, predictive model to support early-stage decision-making.
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The Solution: From “Blank Page” to Peer-Reviewed Standard
I spearheaded this project from its inception, drafting the manuscript from scratch and managing the technical narrative through the entire development cycle.
- Unified Modeling Narrative: I constructed a narrative that integrated data from human FcRn (hFcRn) Tg32 transgenic mice, cynomolgus monkeys, and clinical human profiles into a single, cohesive population PK model.
Quantifying Mutation Impact: The model successfully quantified that LS and YTE mutations reduce clearance by approximately 69% and 75% respectively , translating to half-life extensions that were statistically conserved across species.
Rigorous Editorial Defense: I managed the submission to a top-tier Taylor & Francis journal, where the work received conditional acceptance with only minor corrections. This validated my ability to present complex allometric scaling and body-weight dependency (coefficients of ~0.74 for clearance) to a highly skeptical peer-review audience.
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The Result: A “Ready-to-Deploy” Translational Tool
Although the paper is currently undergoing strategic updates before final release, the framework stands as a powerful tool for predicting human PK from preclinical data. It offers developers a way to assess target druggability and dosing feasibility long before the first human dose is ever administered.
Digital Marketing
D2C Performance Copywriting in Cosmeceuticals
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Scaling Premium Skincare through Expert-Led Narrative Strategy
The Client: Venture Beyond (Third party client (Confidential))
The Project: High-Conversion Landing Pages (SEO & ROAS Optimised)
The Role: Editorial Consultant & Regulatory Copywriter
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The Challenge: Balancing Clinical Authority with D2C Conversion
In the highly competitive US skincare market, brands must navigate a narrow path between persuasive marketing and the strict regulatory framework of the FDA/FTC cosmetics guidelines. Venture Beyond’s third party required a series of landing pages that leveraged the authority of independent dermatologists to compare premium products against industry giants like Neutrogena and Lancôme.
The challenge was to capture the nuance of expert clinical interviews and “translate” them into a high-converting digital format that adhered to the brand’s specific style guides and U.S. marketing regulations.
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The Solution: The “Expert-Witness” Editorial Approach
I served as the editorial bridge between medical expertise and consumer engagement. My process focused on Strategic Transcription & Content Engineering:
Clinical Synthesis: I synthesised raw interview data from dermatologists (including Dr. Jessica and Dr. Dana) to ensure that the final copy was a factually accurate reflection of their expert opinions.
Regulatory Navigation: I engineered the copy to meet the stringent requirements of U.S. cosmetics marketing, ensuring that all “age-defying” and “restorative” claims were framed within a compliant, evidence-based narrative.
Direct-to-Consumer Optimisation: Each page was built for high-performance traffic, using SEO and ROAS-driven copywriting techniques to maximise user engagement and trust.
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The Result: High-Authority Digital Assets
The project resulted in several key high-performing assets, including comparative analyses (“Neutrogena vs. Naked & Thriving”) and top-tier product roundups (“5 Top Age-Defying Eye Creams”). These pages successfully combined medical credibility with commercial impact, driving traffic through a narrative of transparency and clinical efficacy.
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Scaling a Global Luxury Brand in the U.S. Market
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(In-House)
Driving a 30% Revenue Lift through Full-Funnel Narrative Strategy
The Client: Venture Beyond (Third Party Client (Confidential): A Global Luxury Travel & Luggage Leader)
The Project: B2B Case Study & Performance Marketing Analysis
The Role: Senior Copywriter & Growth Journalist
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The Challenge: Translating Fragmented Data into a Winning Narrative
A well-established European luxury brand with a 70-year history was struggling to transition from traditional retail to a dominant direct-to-consumer (D2C) presence in the U.S.. While Venture Beyond had achieved remarkable technical results, including a 30% increase in revenue and a 14% growth in contribution margin, there was no cohesive narrative to “sell” this success to stakeholders or future investors.
I was commissioned to interview the growth and creative teams to “extract” the strategy and distill it into a high-impact B2B case study that explained the mechanics of this scaling success.
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The Solution: Engineering the “Creative Loop”
I didn’t run the ad accounts, but I was the architect of how this story was told. I translated complex performance metrics into a clear, full-funnel strategy:
Pillar 1: Performance-Driven Creative: I articulated how shifting from “branding-heavy” content to “performance-driven” assets (product videos, lifestyle GIFs, and interactive carousels) corrected a critical disconnect in the customer journey.
Pillar 2: Growth Strategy & Unit Economics: I detailed the sophisticated financial management that achieved a 35.21% operating profit margin. This involved explaining the move from simple margin-chasing to maximising Total Profit through SKU optimisation and logistics analysis.
Pillar 3: AOV & Upselling Mechanics: I documented the three-fold strategy that increased Average Order Value (AOV) by 10%. This included mapping out in-cart and post-purchase upsells that raised the revenue share of high-value luggage sets from 10% to 21%.
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The Result: A Historic Milestone
The resulting case study chronicled the brand’s two highest sales dates in history ($267,861 and $215,222 in a single day). By “closing the creative loop” in the narrative, I provided a blueprint for how data-driven media buying can transform a legacy brand into an e-commerce powerhouse.
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Rebranding a Legacy Arts Institution
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(Link)
Defining the Voice of the Actors’ Trust for a New Generation
The Client: Actors’ Trust (In collaboration with I.E. Digital)
The Project: Full Website Rebrand & Copywriting Suite
The Role: Lead Copywriter & Narrative Strategist
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The Challenge: Balancing Heritage with Accessibility
The Actors’ Trust is a venerable institution with a mission to support professionals in the arts during times of crisis. However, legacy brands often struggle with a “new lease of life”, they need to maintain their historic prestige while appearing modern, approachable, and vital to a younger, digital-native audience.
Working alongside the marketing agency I.E. Digital, I was tasked with writing the copy for the entire website. The objective was to create a cohesive narrative that honoured the Trust’s history while clearly articulating its modern support services to those in need.
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The Solution: Strategic Brand Refurbishment
I acted as the “narrative bridge” between the technical structure provided by the agency and the deep well of internal information provided by the Trust. My focus was on Institutional Empathy:
Brand Voice Architecture: I developed a tone of voice that was authoritative yet deeply supportive, essential for an organisation dealing with sensitive welfare and financial aid.
Full-Site Narrative Flow: From the homepage to specific service landing pages, I engineered the copy to guide users through the Trust’s history and toward the support they needed with clarity and dignity.
Collaborative Synthesis: I specialised in taking raw institutional data and “distilling” it into engaging, scannable, and emotionally resonant web copy.
- Successful Refurbishment: By aligning the copy with a complete visual rebrand, I helped provide the Trust with a modern digital storefront that successfully drove engagement and reaffirmed its position as a pillar of the UK arts community.
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The Result: A Reinvigorated Digital Presence
The refurb was a resounding success, providing the Actors’ Trust with a refreshed identity that resonates across generations. The project demonstrated my ability to own a brand’s entire digital narrative, ensuring that every touchpoint, from the “About Us” to the “Apply for Help” call-to-action, was consistent, professional, and mission-aligned.
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Reimagining Community Sport for Social Change
(Link)
A Comprehensive Brand Refurbishment for StreetGames
The Client: StreetGames (In collaboration with I.E. Digital)
The Project: Full Website Rebrand & Digital Copywriting Suite
The Role: Lead Copywriter & Narrative Strategist
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The Challenge: Modernising a National Social Impact Brand
StreetGames is a major UK charity dedicated to changing lives through “Doorstep Sport” in underserved communities. While the organisation had a massive real-world impact, its digital presence required a complete refurbishment to better reflect its dynamic, community-focused energy and to streamline engagement with partners, volunteers, and donors.
Working in an adjacent partnership with I.E. Digital, I was tasked with rewriting the copy for the entire platform, translating the charity’s complex social mission into a vibrant, accessible digital narrative.
The Solution: Narrative Synergy & Community Voice
I focused on creating a “voice of action” that resonated with both high-level stakeholders and the local communities the charity serves:
Empowerment-Led Copywriting: I developed a brand voice that was both professional and grassroots-friendly, emphasising the transformative power of sport in “tackling poverty and its effects.”
Full-Platform Content Architecture: I authored the copy for the entire digital refurb, ensuring a seamless flow from the charity’s core mission statements to specific landing pages for its various initiatives and volunteer programs.
Stakeholder Information Synthesis: I specialised in taking raw contextual data provided by StreetGames and “distilling” it into high-impact, scannable web copy that drove immediate understanding and action.
Strategic Brand Refresh: By aligning the technical refurb with a fresh editorial strategy, I helped re-establish StreetGames as a modern, vital authority in the social-impact sector.
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The Result: A Reinvigorated Digital Identity
The project resulted in a successful, full-scale brand refurb that better aligns StreetGames’ digital presence with its national reputation. This work highlights my ability to manage the entire lifecycle of a digital narrative, moving from raw institutional information to a polished, high-performing website.
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Health & Wellness Content Strategy
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(Link)
Empowering Patient Journeys through Empathetic Clinical Narrative
The Client: Venture Beyond (Third party client (Confidential))
The Project: Comprehensive Editorial Suite (SEO & Patient Education)
The Role: Lead Content Strategist & Medical Copywriter
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The Challenge: Demystifying Menopause for a D2C Audience
Menopause is an area of health often clouded by misinformation, “brain fog,” and a lack of clear, actionable advice. The goal of Menopause Guide was to create a centralised authority for women seeking to understand everything from Hormone Replacement Therapy (HRT) to the psychological impacts of the transition.
The challenge was to create a massive volume of “Expert-Led” content that felt deeply personal and empathetic while navigating the complex physiological realities of weight loss, intimacy, and sleep hygiene during menopause.
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The Solution: The “Patient-First” Narrative Architecture
I was the sole author and strategist behind the platform’s core editorial pillars. My approach focused on Emotional Intelligence combined with Clinical Literacy:
Hormonal Health Education: I authored deep-dive explorations into hormone therapy, translating the “does it work?” question into a balanced, evidence-based narrative for patients considering clinical intervention.
Holistic Symptom Management: I developed a suite of high-performance articles covering “Brain Fog,” sleep rejuvenation, and weight loss obstacles, distilling complex endocrinology into accessible, life-improving strategies.
Sensitivity & Engagement: For sensitive topics like intimacy and body image, I engineered the copy to build immediate trust, moving beyond surface-level advice to address the core obstacles to wellness and rejuvenation.
- Strategic SEO Integration: Every article was built to serve as an SEO cornerstone, driving organic traffic to the platform by answering the specific, high-intent questions women ask during their menopause journey.
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The Result: A Trusted Digital Health Resource
The project resulted in a robust, multi-disciplinary educational platform (MenopauseGuide.co) that functions as a high-authority bridge between clinical possibility and patient reality. By prioritising a “Patient-First” voice, I created a narrative environment where complex medical transitions are met with clarity and empowerment.
High-Volume SEO & Digital Content Strategy
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Scaling Online Visibility through Multi-Disciplinary Narratives
The Client: Click Intelligence (Marketing Agency)
The Project: High-Volume SEO Content Generation
The Role: Senior Content Creator & Ghostwriter
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The Work: Precision Writing at Scale
To support a wide-reaching digital marketing strategy, I produced a high volume of authoritative blog posts, articles, and web copy tailored specifically to boost search engine rankings while maintaining reader engagement. This role required the rapid synthesis of complex information across multiple domains, ranging from Healthcare and Clinical Psychology to Science, Technology, and Business.
The primary objective was to deliver consistent, high-quality output under tight deadlines, ensuring that every piece of content was optimised for search algorithms while remaining aligned with various brand voices.
Academia
The Science of Persuasion & Analytical Rigour
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Project: Doctoral Thesis — Expressive Fictionalism (University of Birmingham)
The Challenge
To solve a long-standing problem in meta-ethics: how do we use language to express moral “truths” when those truths don’t have a physical, scientific presence in the world? This required bridging the gap between abstract philosophy, neurology, and cognitive psychology to understand how the human brain processes complex, non-literal information.
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The Methodology
Multidisciplinary Synthesis: Combined linguistic analysis with empirical research from neurology to test how audience psychology dictates the “acceptance” of a narrative.
Structural Logic: Developed a framework, Expressive Fictionalism, to explain how language shapes perceptions, emotions, and beliefs.
Technical Clarity: Translated dense, theoretical concepts into a 200+ page coherent argument that stood up to rigorous academic defence.
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The Result
Precision Tooling: The ability to construct evidence-based cases and tailor complex data for diverse audiences.
Cognitive Architecture: An expert-level understanding of how readers absorb information, which I now apply to making PKPD models and pharmaceutical bids “sticky” and persuasive.
The “Writer-Scientist” Hybrid: Proved that a deep mastery of language is the most effective tool for explaining complex science.
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Why this matters for Pharma: > My PhD wasn’t just about words; it was about the mechanics of how information moves a mind to action. In the world of MIDD and multi million dollar clinical trials, my role is to architect the narrative that ensures regulators and stakeholders understand its value.